Abstract. The most terrible complication of coronavirus infection is chemical pulmonitis which leads to anoxia accompanied by vasospasm and thrombosis of capillaries. In Russia, the scientist A.G. Chuchalin, in such cases, recommends using helium, which contributes to reduction of anoxia, NO and vasospasm. Helium normalizes gas composition of blood and restores acid-alkaline balance of the blood, and also can prevent anoxia, which prevents complications of coronavirus infections. But all this requires special equipment and well-trained experts. The possibility of application of blood laser irradiation (BLI) in coronavirus infection was estimated, basing on the study whose purpose was to prevent chemotherapy complications in oncological patients by BLI method. The study included 110 children with malformations who were exposed to high-dosage chemotherapy. To prevent oral mucositis (OM), these children got BLI treatments with 1st-class Rikta 04/4 apparatus. To evaluate BLI efficiency before beginning of the treatments and after their ending, phagocyte activity of leucocytes was defined, bacteriological crops of mouth cavity microflora were studied; in order to evaluate microcirculatory changes of capillary blood flow, laser Doppler flowmetry was done. As a result, of 110 children, only one child (0.9%) has had OM. The study showed that this method allows to increase immunity, enhances oxygen supply, relieves vasospasm, and prevents thrombus formation in the vessels. All these BLI features give a basis for use of this method in coronavirus infection.